I've long had an interest in multidrug efflux pumps- proteins that sit in the membrane and make bacteria resistant to a broad range of drugs by pumping the compounds out of the cell. A major focus of multidrug efflux research has been trying to understand how a single protein can recognise a variety of structurally distinct compounds, and I'm sure Eitan will have interesting insights in this area.
Theoretical model of the MdfA protein taken from the Weizmann Institute web site |
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